Whereas Barcelona regained prime spot, forward of Atletico Madrid, La Actual are left in ninth place.
The defeat follows a slender Copa del Rey semi-final first leg 1-0 loss to Actual Madrid in midweek.
Clearly, United had a gruelling extra-time tie to cope with on Sunday, plus the ache of exiting the FA Cup to Fulham by way of a penalty shootout, however will likely be seeking to obtain a optimistic lead to San Sebastian on Thursday.
The round-of-16 first leg kicks off at 17:45 GMT and is dwell on TNT Sports activities within the UK.
